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gci@uaslp.mx
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Researcher profile


José G. Sampedro Pérez

Personal Data:
Academic Degree:  PhD Degree
SNI Level: II
SCOPUS ID: 7004296237
Institutional Data:
Affiliation: Faculty of Sciences
Research Unit: Institute of Physics

Office address: Manuel Nava 6 Zona Universitaria CP. 78290 San Luis Potosí
Phone number: (+52) 4448262300
Ext.: 5715
Email: jose.sampedro@uaslp.mx
  1. PhD Degree in PhD (Biochemistry)
    Universidad Nacional Autónoma De México
  2. Bachelor's Degree in BsC (Chemistry and Pharmaceutical Biology)
    Universidad Autónoma Metropolitana

In our laboratory  we study the structure-function relationship in P-type ATPases
(H -, Na ,K , and Ca2 -ATPases). We are also focused in the stabilization of proteins (enzymes)
under denaturing conditions such as heat, dehydration (lyophilization), oxidative stress
and by chemical compounds. We usually perform in the lab protein engineering,
purification of native and recombinant proteins. As biophysicists, we study the
effect of the rheology of the aqueous medium on enzymatic activity applying Kramers´ theory,
we perform also the analysis of structural dynamics in proteins using spectrophotometric
techniques (fluorescence and dichroism circular). We study also the chemical modification
of proteins and their effect on stability and activity. The determination of stabilizing
mechanism of enzymes by trehalose and other compatible solutes is also a matter of study
in our laboratory.
  1. Las bombas primarias P-ATPasas: Estructura cuaternaria, mecanismos de regulación y estabilización
    01/07/2012 - 15/07/2016
    SEP-CONACYT