The goal of my laboratory is to study the functional and structural basis of ionic channels in the plasma membrane. These transmembrane proteins allow the flux of ions ( Ca² , Na , K or Cl^-) involved in important physiological processes such as electrical excitability, hormone and neurotransmitter release, excitation-contraction coupling and gene expression regulation. The activity of ion channels is modulated by interactions with other membrane proteins or lipids, or by external and intracellular signaling molecules. Our main goal is to identify and characterize the molecular elements and mechanisms involved in both the basal activity and modulation of ion channels. To this end, we use a variety of experimental approaches, including cell isolation and culture, biochemical and molecular biology techniques, and patch-clamp recording.

1. Functional and structural aspect of voltage-dependent calcium channels modulation
2. Effect of cholesterol on biophysical properties of plasma membrane
3. Modulation of voltage-dependent calcium channels by membrane receptors
4. Ionic channels modulation by plasma membrane lipids

1. Integrative Cardiorenal Physiology
2. Biomembranes

1. Biofísica estructural y funcional de las membranas biológicas
   15/07/2015 - 15/07/2025
   CONACyT
2. Caracterización funcional y molecular de variantes del canal de calcio CaV2.1 asociadas con enfermedades neurodegenerativas.
   06/01/2020 - 12/08/2024
   UASLP
3. Interacciones entre canales iónicos y lípidos en la membrana plasmática
   03/03/2017 - 03/03/2020
   CONACyT