Diana P Portales Pérez is a Pharmaco-biologist with a doctoral degree in Basic Biomedical Sciences. She has been recognized with the distinction of level III member of the National System of Researchers (SNI) and a PRODEP profile. Her research is focused on the field of Biomedical Sciences, with an emphasis on Immunology, allowing her to make significant contributions to the understanding of pathogenesis and the discovery of molecular and cellular biomarkers in non-communicable diseases.

Current projects:

Epigenetic modifications of the enzymes N Acetyltransferases 1 and 2 (NAT1 and NAT2) and their role in the carcinogenesis process in acute lymphoblastic leukemia as well as their role related to insulin resistance and metabolism of regulatory T cells in patients with type 2 diabetes mellitus in the search for potential therapeutic targets.

Evaluation of microRNAs, polymorphisms of ABC transporters, and purinergic receptors related to chemoresistance and progression in breast cancer.

Evaluation of the effect of the consumption of synbiotics on the microbiota, levels of short-chain fatty acids (SCFA), and the expression of GPR43 and 41 receptors as well as circulating microRNAs in children who are overweight and obese to support prevention in the development of type 2 diabetes mellitus, cardiovascular diseases, dyslipidemias, and the appearance of certain types of cancer in adulthood.

Effect of tumor microenvironment on macrophage differentiation, interferon regulatory factor-8, and mitochondrial damage on breast cancer progression.

1. Immunology
2. Immunometabolism
3. Immunogenetics
4. Public Health and Immunology
5. Toxigenomic
6. Study on genetic, epigenetic, and immunological regulation mechanisms in chronic metabolic, inflammatory diseases (obesity/diabetes), and cancer. Specifically, immune, and inflammatory regulation biomarkers such as regulatory T cells and microRNAs.

1. Immunology and Immunogenetics
2. Public Health
3. Biochemistry of Desease
4. Toxigenomics

1. Caracterización del secretoma inducido por la comunicación tumor-macrófago: búsqueda de marcadores de agresividad en cáncer de mama.
   07/07/2021 - 10/07/2024
   Fronteras de la Ciencia 2020